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The Tumey group is broadly focused on the medicinal chemistry of targeted drug-delivery technology.  More specifically, the majority of our efforts are devoted to the design and application of antibody-drug-conjugates (ADCs). There are now 8 FDA-approved ADCs for the treatment of cancer.  As shown in the graphic below, our research projects are aimed at various aspects of ADC design – including the selection of appropriate antibody targets, the optimization of the ADC linker, the identification immunomodulating payloads, and the optimization of new conjugation chemistry.

Contact Dr. Tumey if you are interested in collaborating with us on these projects. Our lab is fully equipped to perform organic synthesis, pharmacology, and in vitro immunology.  A list of relevant equipment available in our department includes:

  • Waters Acquity UPLC (H-class) with QDa quadrupole MS and fluorescence detector
  • Bruker Avance III HD 400 mHz NMR
  • Bio-Rad NGC chromatography system with quad-wavelength detector
  • Waters Autopurification HPLC system with SQD2 quadrupole MS
  • Orbitrap Mass Spectrometer (Q-Exactive HF)
  • Isco Combiflash Rf
  • Tissue culture hoods / CO2 incubators
  • Chemical fume hoods
  • Speedvacs / rotovaps
  • Leica DMi8 CEL Advanced Confocal Microscope
  • Various centrifuges
  • NanoDrop 2000
  • Agilent Cary 60 UV-Vis Spectrophotometer
  • Molecular Devices i3x plate reader
  • Azure c300 CCD imager for Western blot and DNA gels
  • The MSD Meso QuickPlex SQ120
  • Multiple -80 °C, -20 °C, and 4 °C fridges/freezers
  • Liquid N2 cryopreservation system

See this link for more specific information on our instrumentation. Note that some of this equipment is available to external researchers on a fee-for-service basis.  Please contact Dr. Tumey for details.

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